ABSTRACT
Introduction: Appendicitis is the most common causeof surgical abdomen in all age groups with a lifetime riskof 6%. The role of laparoscopic appendicectomy remainscontroversial as many researchers have suggested thatoverall morbidity is primarily a function of the degree of theappendicitis rather than the operative approach. The presentstudy was designed to compare the outcome of laparoscopicappendicectomy versus open appendicectomy in a tertiarycare hospital.Material and methods: This was a randomized controlledstudy on 100 cases of acute appendicitis operated inRohilkhand Medical College, Bareilly in a period of one year.The patients were randomly assigned to two groups of 50 eachoperated by open and three port laparoscopic surgery.Results: Abdominal pain (100%) was the commonestpresenting complaint. Retrocaecal anatomical position (76%in open, 70% in lap. appendicectomy) of the appendix wasthe commonest operative finding. Wound infection rate (8%)was insignificantly higher in open appendicectomy. Therewas significantly less operative time, postoperative painbetter cosmesis and early return to normal daily activity inlaparoscopic as compared to open appendicectomy.Conclusion: Laparoscopic appendicectomy is better ascompared to open appendicectomy in terms of post-operativecomplications, post-operative pain, hospital stay, early returnto normal activity, and subjective cosmesis.
ABSTRACT
Aim: The study was carried out with an aim to evaluate an association of serum lipid profile with breast carcinoma and benign breast disease. Methods: For this purpose, a case-control study was planned in which a total of 105 subjects were enrolled according to a purposive sampling design - A total of 35 (33.3%) patients in each group having breast carcinoma, benign breast disease, and healthy controls were included for assessment. Lipid levels were assessed. Data were analyzed. Results: Age of subjects enrolled in the study ranged from 16 to 58 years. The mean age of subjects in malignant, benign and control group was 45.71 ± 10.04, 24.91 ± 6.83 and 35.60 ± 12.42 years, respectively. The majority of malignant cases were in advanced stage (T3 and T4), together accounted for 94.29% of total malignant cases. The remaining 2 (5.7%) cases were in T2-stage. A total of 21 (60%) cases had metastasis too. Mean triglyceride (TG) levels of malignant cases were significantly higher as compared to that of benign and healthy controls. Mean serum high density lipoproteins levels were significantly higher in benign group as compared to healthy controls. Mean serum low density lipoproteins levels were maximum in healthy controls and minimum in benign breast disease group. Statistically, the difference between healthy controls and benign breast disease was also found to be significant. Conclusion: For different lipid components, the relationship with different types of breast lesions was found to be varying. In malignant cases, TG levels showed an increased trend. The possibility of these relationships being random cannot be ignored. A larger study on larger sample size is recommended.